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Abstract Environmental seismic disturbances limit the sensitivity of LIGO gravitational wave detectors. Trains near the LIGO Livingston detector produce low frequency (0.5– $10\mathrm{H}\mathrm{z}$) ground noise that couples into the gravitational wave sensitive frequency band (10– $100\mathrm{H}\mathrm{z}$) through light reflected in mirrors and other surfaces. We investigate the effect of trains during the Advanced LIGO third observing run, and propose a method to search for narrow band seismic frequencies responsible for contributing to increases in scattered light. Through the use of the linear regression tool Lasso (least absolute shrinkage and selection operator) and glitch correlations, we identify the most common seismic frequencies that correlate with increases in detector noise as 0.6– $0.8\mathrm{H}\mathrm{z}$, 1.7– $1.9\mathrm{H}\mathrm{z}$, 1.8– $2.0\mathrm{H}\mathrm{z}$, and 2.3– $2.5\mathrm{H}\mathrm{z}$in the LIGO Livingston corner station. 

Abstract Understanding the noise in gravitational-wave detectors is central to detecting and interpreting gravitational-wave signals. Glitches are transient, non-Gaussian noise features that can have a range of environmental and instrumental origins. The Gravity Spy project uses a machine-learning algorithm to classify glitches based upon their time–frequency morphology. The resulting set of classified glitches can be used as input to detector-characterisation investigations of how to mitigate glitches, or data-analysis studies of how to ameliorate the impact of glitches. Here we present the results of the Gravity Spy analysis of data up to the end of the third observing run of advanced laser interferometric gravitational-wave observatory (LIGO). We classify 233981 glitches from LIGO Hanford and 379805 glitches from LIGO Livingston into morphological classes. We find that the distribution of glitches differs between the two LIGO sites. This highlights the potential need for studies of data quality to be individually tailored to each gravitational-wave observatory. 

Previous work demonstrated an accelerated in vitro and in vivo wound healing response when insulinoma cells were used to deliver insulin to scratches in keratinocyte mono- layers and chronic diabetic excise wounds in mice, respectively. When combined with mesenchymal stem cells (MSCs), the response was amplified (healing in 14 vs. 35+ days). To isolate the role of insulin in the response and exclude any potential contribution of an unknown cancer moiety released by the insulinoma cells, the effect on wound healing of multiple lines derived from the same insulinoma was examined. 

Previous work demonstrated an accelerated in vitro and in vivo wound healing response when insulinoma cells were used to deliver insulin to scratches in keratinocyte mono- layers and chronic diabetic excise wounds in mice, respectively. When combined with mesenchymal stem cells (MSCs), the response was amplified (healing in 14 vs. 35+ days). To isolate the role of insulin in the response and exclude any potential contribution of an un known cancer moiety released by the insulinoma cells, the effect on wound healing of multiple lines derived from the same insulinoma was examined. 

Abstract Progress in gravitational-wave (GW) astronomy depends upon having sensitive detectors with good data quality. Since the end of the Laser Interferometer Gravitational-Wave Observatory-Virgo-KAGRA third Observing run in March 2020, detector-characterization efforts have lead to increased sensitivity of the detectors, swifter validation of GW candidates and improved tools used for data-quality products. In this article, we discuss these efforts in detail and their impact on our ability to detect and study GWs. These include the multiple instrumental investigations that led to reduction in transient noise, along with the work to improve software tools used to examine the detectors data-quality. We end with a brief discussion on the role and requirements of detector characterization as the sensitivity of our detectors further improves in the future Observing runs. 

The Heisenberg uncertainty principle dictates that the position and momentum of an object cannot be simultaneously measured with arbitrary precision, giving rise to an apparent limitation known as the standard quantum limit (SQL). Gravitational-wave detectors use photons to continuously measure the positions of freely falling mirrors and so are affected by the SQL. We investigated the performance of the Laser Interferometer Gravitational-Wave Observatory (LIGO) after the experimental realization of frequency-dependent squeezing designed to surpass the SQL. For the LIGO Livingston detector, we found that the upgrade reduces quantum noise below the SQL by a maximum of three decibels between 35 and 75 hertz while achieving a broadband sensitivity improvement, increasing the overall detector sensitivity during astrophysical observations. 

Abstract The Gravitational-Wave Transient Catalog (GWTC) is a collection of short-duration (transient) gravitational-wave signals identified by the LIGO–Virgo–KAGRA Collaboration in gravitational-wave data produced by the eponymous detectors. The catalog provides information about the identified candidates, such as the arrival time and amplitude of the signal and properties of the signal’s source as inferred from the observational data. GWTC is the data release of this dataset, and version 4.0 extends the catalog to include observations made during the first part of the fourth LIGO–Virgo–KAGRA observing run up until 2024 January 31. This Letter marks an introduction to a collection of articles related to this version of the catalog, GWTC-4.0. The collection of articles accompanying the catalog provides documentation of the methods used to analyze the data, summaries of the catalog of events, observational measurements drawn from the population, and detailed discussions of selected candidates. 

Abstract We report the observation of gravitational waves from two binary black hole coalescences during the fourth observing run of the LIGO–Virgo–KAGRA detector network, GW241011 and GW241110. The sources of these two signals are characterized by rapid and precisely measured primary spins, nonnegligible spin–orbit misalignment, and unequal mass ratios between their constituent black holes. These properties are characteristic of binaries in which the more massive object was itself formed from a previous binary black hole merger and suggest that the sources of GW241011 and GW241110 may have formed in dense stellar environments in which repeated mergers can take place. As the third-loudest gravitational-wave event published to date, with a median network signal-to-noise ratio of 36.0, GW241011 furthermore yields stringent constraints on the Kerr nature of black holes, the multipolar structure of gravitational-wave generation, and the existence of ultralight bosons within the mass range 10⁻¹³–10⁻¹²eV.